L-Se-Methylselenocysteine CAS 26046-90-2

Product Description:

Name: L-Selenium-methylselenocysteine,

L-Se-methylselenocysteine (L-SeMC) is a natural L-type selenium-containing amino acid and a methylated derivative of selenocysteine, the 21st essential amino acid for human body. It has been approved as a third-generation nutritional enhancer by China CFDA (China Food and Drug Administration, Announcement No. 11 of 2009 on New Food Additives) and the US FDA (US Food and Drug Administration). It was first isolated from Astragalus in 1960. It is widely found in selenium-rich plants such as broccoli, garlic, onion, wild leek, etc., and is the best source of selenium for human nutrition. It is an easily absorbed form of organic selenium with multiple effects such as tumor inhibition, anti-oxidation, anti-aging, auxiliary treatment of cardiovascular diseases, detoxification, etc. L-Se-methylselenocysteine is a compound similar to methionine, and its side chain contains methyl selenium. This compound can bind to glutathione peroxidase to play an antioxidant role and has obvious preventive function.

Advantages:
L-Se-methylselenocysteine is decomposed into methylselenol by the action of β-lyase in the body. Compared with organic or inorganic selenium supplements such as selenomethionine, it has the following advantages:
1. Safety
It has low toxicity at high doses and is not easy to accumulate in the body. It will not be non-specifically embedded in proteins.
2. High absorption rate
It has a high absorption rate and can be directly used by the human body. The human body cannot synthesize selenium on its own, so it must be ingested exogenously. The absorption rate of organic
selenium is as high as 80%, which is much higher than the 50% of inorganic selenium.
3. Medical value
L-SeMC has been shown to have multiple biological functions, the main effects are as follows:

• Anti-cancer effect: directly generate anti-cancer active substance methylselenol. Studies have shown that methylselenol is a key metabolite of selenium in cancer prevention and a core form of its anti-cancer activity mechanism. At the same time, it inhibits ERK1/2 signaling through a ROS-dependent pathway and exerts anti-tumor activity in anaplastic thyroid cancer (ATC) cells.
• Anti-aging: Studies have found that L-SeMC can improve neuropathology and cognitive defects in Alzheimer's disease models. L-SeMC was found to regulate oxidative stress, metal homeostasis and extracellular signal-regulated kinase (ERK) activation, thereby improving AD-related neuropathology and cognitive defects.
• Other effects: anti-oxidation, improving immunity, treating cardiovascular diseases, detoxifying heavy metals, treating and preventing Keshan disease, Kashin-Beck disease, etc.

Application:

1. In the pharmaceutical industry
L-SeMC is widely used in the pharmaceutical industry due to its unique biological functions and safety. Its applications mainly cover the following aspects: First, L-SeMC is used to treat selenium deficiency, because selenium is an essential trace element for the human body, and selenium deficiency can lead to a variety of diseases. As an effective drug, L-SeMC can supplement selenium and improve the symptoms of patients with selenium deficiency. Secondly, L-SeMC exhibits the characteristics of inhibiting tumor cell growth, so it can be used to prevent and treat a variety of cancers, including breast cancer and lung cancer. L-SeMC has been used in clinical trials to study the prevention of prostate cancer. In the cardiovascular field, L-SeMC has antioxidant, anti-inflammatory and lipid-lowering effects, which can reduce the risk of cardiovascular diseases, including coronary heart disease, hypertension and heart failure.
2. In the nutritional health care industry
L-Selenium-methylselenocysteine can be used as a nutritional health care product to prevent cancer, cardiovascular disease,neurodegenerative diseases, etc. Studies have shown that L-SeMC can inhibit the growth of tumor cells and reduce the risk of cancer; it can lower blood lipids and blood pressure and prevent cardiovascular diseases; it can promote the growth and regeneration of nerve cells and has potential preventive and therapeutic effects on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
3. In the feed additive industry
L-SeMC can be used as a feed additive to improve the production performance and health level of livestock and poultry and prevent selenium deficiency. Studies have shown that L-SeMC can increase the egg production rate, egg weight and feed conversion rate of broilers, improve the growth rate and feed conversion rate of pigs, and reduce the incidence of mastitis in dairy cows.